It is forty years into the future and, following decades of research and trillions of euros spent on genetics, Europe is finally in a position to rejuvenate a human being. The first subject is Jeff Baker, the father of the datasphere (which replaced the Internet) and philanthropist extraordinaire. After eighteen months in a German medical facility, the seventy-eight-year-old patient returns home looking like a healthy twenty-year-old. Misspent Youth follows the effect his reappearance has on his family and friends - his young ex-model wife Sue, his teenage son Tim, and his long-term pals, themselves all pensioners, who are starting to resent what Jeff has become.